P/F PROGRAM

PILOT PROJECTS

The Hopkins Conte Digestive Diseases Basic and Translational Research Core Center (jhugicc.org/) was established in June of 2011 to advance fundamental and translational gastrointestinal research at Hopkins. The Core mission is to bring together GI investigators and encourage others in the community to enter this area of research. This is accomplished by:

    1. Providing cutting-edge resources that are too expensive or labor-intensive to be maintained by most individual laboratories; and
    2. Generating an environment that supports the intellectual activities of Center members through seminars, symposia, and work-in-progress updates on GI-related research
    3. Funding Pilot/Feasibility projects

The Pilot/Feasibility Projects (P/FP) are key components of Core activities.  The goal of this program is to provide seed money for projects, eventually leading to successful competition for funding at the national level. The P/FPs provide $10,000-$25,000, typically given each year to up to 4 investigators/projects. Alternatively, up to $50,000 can be awarded for collaborative projects between a new investigator and a more senior investigator (#2 under Eligibility below).  There is no requirement for permanent residence status or US citizenship.  Preference is given to young investigators (see criteria of eligibility below); funding is usually for one year. All recipients of P/FP project funding are required to submit a yearly update on their progress for 5 years and formal presentation of progress after the 2nd year.

Eligibility

    1. New investigators, who have never held extramural NIH support other than a K or R03 award and have not been PIs on R, P, or U grants, are the preferred group for funding. Those with MD, PhD, or MD/PhD are eligible and applicants should be junior faculty or will be junior faculty at the start of this funding.
    2. New investigators (as in #1 above) can apply in collaboration with a more senior investigator as a co-principal investigator. These awards can be up to $50,000. These funds may be shared between the investigators, for example, if the senior PI contributes specialized reagents, access to unique instruments, or licensed software. A detailed budget is required for these applications, and a majority of the funds should be designated to the junior investigator.
    3. Established investigators who are interested in entering the GI field and initiate the GI-related projects.
    4. GI investigators who are starting a new, innovative project that represents a significant departure from their ongoing, funded research.

     

    The order above (1=2>3>4) represents the priority for selecting projects for funding. Investigators may generally receive P/F support only once in any 5-year period. Consideration can be given for a second year upon submission of a formal application, which must include a progress report.

    We especially welcome applications from underrepresented minorities, women, and individuals with disabilities.

REQUIREMENTS OF PILOT PROJECTS

  1. The proposed research must be related to a GI topic.
  2. The project proposes to use one or more Center Cores resources/services. Information about Cores can be found here.
  3. The P/FPs awardees are expected to participate and present their research at a Center’s work-in-progress meeting. Junior investigators are required to meet with a committee after six months of funding, to review progress.
  4. Our center is judged on how many R or P grants result from the pilot projects. Priority for funding will be in part based on the potential to lead to such funding.

PROPOSAL DETAILS

    1. Applications are submitted electronically (by e-mail) by (TBA) to Ms. Esther Choi (echoi34@jhmi.edu). Only fully completed applications that follow the format described below will be considered.
    2. The $10,000-$25,000, or up to $50,000 for collaborative projects, for one year can be used to cover expenses for salary (technician, postdoctoral fellow, NOT faculty), supplies, animals.
    3. Format:
    • Cover page (Please use the form), which includes title, abstract up to 250 words (can be Arial 10), and pending/approved IACUC/IRB protocols.
    • NIH Biosketch of applicant and mentor (if applicable).
    • Applicant’s other support (salary source, etc).
    • Budget and Justification for funds requested.
    • Specific Aims, Background, Preliminary Results, Research Plan, Future Directions: total 3 pages, font size Arial 11.
    • Plans to apply for extramural funding: topic and time frame: 1 page
    • References: 1 page.
    • Letter from PI, mentor(s), Department Chair or Division Chief stating how this project will allow you to advance independence and further your career, with emphasis on establishing independence.

REVIEW PROCESS

The Center’s External Scientific Advisory Committee will review the proposals based on the eligibility criteria. An interview may be offered.

For additional information please contact Ms. Esther Choi (echoi34@jhmi.edu), Dr. J. Hamilton (jpahamilton@jhmi.edu), and/or Dr. J. Pluznick (jpluznick@jhmi.edu).

DDRC Year 11 P/F Projects have been awarded. We will announce when the next round will be offered.

HISTORY OF P30 PILOT AND FEASIBILITY PROGRAM OUTCOMES

P&F #PI (sex, dept.)Dates/Amount of P&F Award (direct costs)Pilot Project Title (Core Focus Area)P&F CategoryA*PApplications / Grants and Current academic position if changedPending/ FundedProject PeriodStill in DD Research?
1Ayman Koteish, MD

Male, Med
2011-2012
($20,000)
EMT and hepatic fibrogenesis

(Basic Pathophysiology)
114R21 application x2; ABIMR application

Now Director of Hepatology/Liver Transplantation, Florida Hospital Center.
Yes
2Florin Selaru, MD

Male, Med
2011-2012
($20,000)
MicroRNAs in Cholangiocarcinoma

(Basic Pathophysiology)
1320K08DK090154; R01EB017742; PatentK08; R01 funded (PI)7/1/11-6/30/10Yes
3Shaoguang Wu, MD

Female, Onc
2011-2012
($20,000)
REG III gene expressing ETBF

(Basic Pathophysiology)
100Yes
4James Hamilton, MD

Male, Med
Epigenetic regulation in hepatocellular carcinoma

(Basic Pathophysiology)
Epigenetic regulation in hepatocellular carcinoma

(Basic Pathophysiology)
13P/F led to collaboration with S. Lutsenko and new research direction
leading to R01 (DK117396) application x3; patent
R01 funded (MPI)5/1/18-4/30/23Yes
5Mariana Lazo, MD, PhD

Female, Med
2012-2013
($25,000)
Liver microRNAs and NASH

(Translational Research)
115R01;
R21; Nexus Award (JHU Award); Now at Drexel Dornsife School of Public Health
R01 funded; Nexus Award Funded9/1/16-7/31/22;

2017
Yes
6Sandra Gabelli, PhD

Female, Med/CMM
2012-2013
($25,000)
NHE3 Structure

(Basic Physiology)
210Yes
7Nicholas Zachos, PhD

Male, Med
2012-2013
($25,000)
Human Enteroid as a Model of Host-Pathogen Interactions

(Basic Pathohysiology)
125U01;
R24;
P01;
TEDCO;
Gates Grand
Challenge;
U01 funded (Co-I);
R24 funded
(Co-I);
P01 funded (Co-I);
TEDCO funded
(PI);
Gates Grand
Challenge
(Co-PI)
9/1/14-8/31/19;
7/1/14-6/30/22;
7/1/16-6/30/26;
7/1/14-4/30/15;
6/1/14-4/30/16
Yes
8Pamela Guerrerio, MD, PhD++

Female, Peds
2013-2014
($25,000)
Mendelian Disorder and Eosinophilic GI Diseases

(Translational Research)
11Now Chief, Food Allergy Research Unit at the NIHYes
9Kathleen Burns, MD, PhD+++
(with H. Kazazian, Ph.D)

Female, Path/Onc
2013-2014
($25,000)
Retrotransposons and GI Cancers

(Basic Pathophysiology)
1a02R01 GM099875
Now Chief, Oncologic Pathology, Dana Farber Cancer Inst.
R01 Funded and refunded7/1/13-3/21/20Yes
10Jennifer Pluznick, PhD++++

Female, Physiology
2013-2014
($25,000)
Gut Microbiota and Hypertension


(Basic Pathophysiology)
122R01DK107726;
R01HL128512;
AHA
R01s funded;
AHA funded
12/1/15-11/30/21;
4/1/16-03/31/21;
1/1/15-12/31/16
Yes
11Arnab Gupta, PhD

Female, Physiology
2013-2014
($25,000)
Trafficking of Cu ATPases

(Basic Physiology)
115Wellcome Trust DBT Now a Fellow, IISER Kolkata, IndiaWellcome Trust-India Alliance;
Ramanujan Fellowship;
MRC Grant
2016-2021;
2015-2020;
2020-2023
Yes
12Shaoyong Yu, MD, PhD

Male, Med
2014-2015
($10,000)
OCT and Eosinophilic Esophagitis

(Translational research)
102R01 DK110366 (M-PI); R01 DK126673R01s funded8/25/18-7/31/21;
9/21/20-8/31/23
Yes
13Ines A Silva, PhD+++++

Female Ped Onc
2014-2015
($10,000)
Intestinal Regeneration in GVH

(Translational research)
100Now at U MichiganNo
14Hai-Quan Mao, PhD++++++

Male, Engineering
Enteroid Platforms

(Basic Physiology)
Enteroid Platforms

(Basic Physiology)
201Associate Director, Institute for NanobiotechnologyNo
15Florin Selaru, MD

Male, Med
2014-2015
($25,000)
Microgrippers in GI Disease

(Translational Research)
104R01EB017742R01 funded and renewed10/02/14–9/31/22Yes
16Takanari Inoue, PhD

Male, Cell Biology
2014-2015
($20,000)
Developing rapidly inducible techniques to reveal molecular identity of polarized epithelial cells

(Basic Physiology)
200R01GM123130R01 funded9/1/18-8/31/23No
17Hari Easwaran, PhD

Male, Onc
2015-2016
($25,000)
Tet-inducible CRISPR/CAS9 and Human Enteroids

(Translational research)
110R01CA230995
R01 CA229240 (Co-I)
R01s funded9/1/18-8/31/23; 7/1/19-6/30/24Yes
18Yoon-Young Jang, MD, PhD

Female, Onc
2015-2016 II
($25,000)
Stem cell derived mini-livers

(Basic Physiology)
105R03 HD0912264;
AASLD RSA
R03 funded;
AASLD funded
7/1/18-6/30/20; 7/1/19-6/30-19Yes
19Hannah Pierson, PhD

Female, Physiology
2015-2016 II
($25,000)
Enteroids and ATP7B

(Basic Pathophysiology)
101Now Senior Scientist, Matrix ART, CalgaryYes
20Julie In, PhD

Female, Med
2016-2017
($25,000)
EspP Damage and Recovery in Human Colonoids

(Basic Pathophysiology)
104K01 DK106323;
DOD Research Award;
AGA CSA Application;
Now at University of New Mexico
K funded;4/1/16-1/31/23Yes
21Amy Kim, MD

Female, Med
2016-2017
($25,000)
Circulating DNA as Predictor of Hepatocellular Carcinoma Outcomes

(Translational research)
103R44 HG008700 (co-I)
U01 CA230690 (co-I)
K08CA237624

DOD Award-PRCRP-USAMRAA : W81XWH-20-1-0605 CA191036
R44 funded;
U01 funded;
K funded;
DOD funded
9/25/18-8/31/20;
8/31/18-8/30/23;
04/01/20-03/30/25
Yes
22Joanna Melia, MD

Female, Med
2016-2017
($25,000)
SLC39A8 in the intestinal inflammatory milieu

(Translational Research)
103K08DK114478;
CCF multicenter Acute Colitis Study;
AGA Elsevier Award
K Funded;
CCF Funded;
AGA Funded
07/01/19-04/30/24;
01/01/18-12/31/19;
07/01/20-06/30/21
Yes
23Nicholas Zachos, PhD

Male, Med
2016-2017
($25,000)
Rotavirus in Human Enteroids

(Translational Research)
1311R01 application x2See also #7Yes
24Jennifer Foulke-Abel, PhD

Female, Med
2017-2018
($25,000)
Cholera Toxin and Cell Cycle Arrest

(Basic Pathophysiology)
111K01DK113043;
P01AI1125181
K01 funded;
P01 funded
3/17-2/22
07/01/21-06/30/26
Yes
25Gabsang Lee, DVM, PhD

Male, Neuro
2017-2018
($15,000)
iPSC Reconstruction of Neuro-Enteroid Model

(Basic Physiology)
201R21 plannedYes
26Tasha Larman, MD+++++++
(with Rong Li , Ph.D)

Female, Path
2016-2017
($25,000)
Niche Factor Independent Growth of Colonoids

(Basic Pathophysiology)
1a01K08 application;
Mark Foundation for Cancer Research
Mark Foundation funded3/1/19-2/28/20Yes
27Lingling Xian, MD, PhD

Female, Med
2017-2018
($20,000)
HMGA1 in Goblet Cell Differentiation and Regeneration

(Basic Pathophysiology)
111R01CA232741 (Co-I)R01 funded07/24/18-06/30/23Yes
28Shadi Yarandi, MD

Female, Med
2017-2018
($20,000)
Antibiotics, GI Motility and ENS Expression

(Basic Pathophysiology)
111K08 application;
AGA CSA application 2019
No
29Clare Lee, MD

Female, Med
2018-2019
($30,000)
Vagus-Enteroids and Bile Acids and Microbiome and Glucose Metabolism

(Translational Research)
100Now at Eskanazi Health, IndianaNo
30Subhash Kulkarni, PhD

Male, Med
2018-2019
($25,000)
Vagus-Enteroids and Organ on Chip

(Basic Physiology)
100R21 application fall
2019;
R01AG066768
R01 funded1/15/21-12/31/25Yes
31Mark Lazarev, MD+++++++ (with A. Meeks, PhD)

Male, Med
2018-2019
($25,000)
Serrated Polys and IBD and Cancer

(Translational research)
1a01Yes
32Janet Markle, PhD

Female, Med
2018-2019
($25,000)
Discovering genes
and mechanisms of
severe inflammatory bowel disease in children

(Translational research)
100Now at Vanderbilt University SOMYes
33G William Wong, PhD

Male, Physiology
2019-2020
($25,000)
CTRP4, in inflammatory bowel disease

(Basic Pathophysiology)
200Yes
34Huimin (Helen) Yu, MD, PhD

Female, Med
2019-2020 II
($25,000)
IBD Colonoids and Inflammation

(Translational research)
110Discovery Fund Challenge Award (JHU)Yes
35Zhaozhu Qiu,
PhD

Male, Physiology
2019-2020 II
($25,000)
Physiologic Functions of Novel Cl Channels

(Basic Physiology)
201Yes
36Varsha Singh, PhD

Female, Med
2020-2021
($25,000)
Defective Goblet cell function in Ulcerative colitis patients

(Translational Research)
110Goblet cells in UC;
CCF
Yes
37Archana Venkataraman, PhD

Female, Elec eng
2020-2021
($15,000)
AI for Neuro-GI: Developing an AI-Driven Software to Construct and Analyze the First Large-Scale Network Map of the Enteric Nervous System

(Basic Physiology)
100Yes
38Deok-Ho Kim, PhD

Male, Bio Med Eng
2020-2021
($25,000)
A Microfluidic Intestine-on-a-Chip for Dynamic Analysis of
Gut Immune System Interactions

(Basic Physiology)
200Yes
39Joanna Melia, MD

Female, Med
2021-2022
($25,000)
Aberrant N-glycosylation in Crohn’s disease

(Translational Research)
100Yes
40Jennifer Foulke-Abel, PhD

Female, Med
2021-2022 ($20,000)Bacterial factors mediating innate immune responses to enterotoxigenic E. coli infection

(Basic Pathophysiology)
110Yes
41Ken Hui, MD, PhD

Male, Med
2021-2022 ($20,000)Anatomic and Molecular Characterization of Tac1-Expressing Neurons in the Murine Nodose Ganglion

(Basic Physiology)
110Yes
42Tatsuya Yamada, PhD

Male, Cell Bio
2021-2022
($25,000)
Role of Megamitochondria in Nonalcoholic Steatohepatitis

(Translational Research)
100Yes

A* Abstracts only included if no full manuscript on topic

P/F Category: 35 Category I; 7 Category 2; 0 Category 3 (Thru yr 11; includes category 1 and 1a)

Core Focus Areas/Themes represented: Basic Physiology, 11; Basic Pathophysiology, 16; Translational research, 15.

+ Active in pharmaceutical sponsored research related to liver transplantation and liver disease
++ Used progress in Pilot Project to obtain tenured position at NIH NIAID, 2015
+++ Former head of JHU MD-Ph.D program
++++ Best example of person whose career was advanced by the P/F
+++++ Left institution in middle of Pilot Project program
++++++ Money returned because he accepted major leadership position in Biomedical Engineering Dept., JHU
+++++++ Young scientist as PI with senior scientist as collaborator and mentor (category 1a)