The Hopkins Digestive Diseases Basic and Translational Research Core Center (DDBTRCC) is a Silvio Conte Core Center which has as its goal to advance basic science and translational digestive diseases research at the Johns Hopkins University School of Medicine. This is expected to improve the health of patients with the broad spectrum of gastrointestinal and hepatic disorders. This National Institutes of Diabetes and Digestive and Kidney Diseases sponsored Center is a continuation of a NIDDK GI Core Mini Center which was funded for 8 years and dealt with the themes common to this new Center. This Core Center has as its major research theme, “Regulation of Epithelial Function, especially via changes in signal transduction, trafficking and development."

The major areas being studied include: 1) Epithelial Transporter Function and Regulation, including trafficking, protein-protein interactions and bioinformatics. 2) Inflammation, fibrosis and cancer development, including infectious diarrheal diseases, inflammatory bowel diseases, fatty liver, alcoholic and non-alcoholic steatohepatitis, obesity, eosinophilic esophagitis, and pancreatitis. 3) Pancreatic Development Biology. 4) Epigenetic Aspects of GI Cancer. The Cores that make up this Center include, in addition to an Administrative Core, Proteomics Core, Integrated Physiology Core, Imaging Core, and Translational Research Enhancement Core.

About This Center The Hopkins Center is an NIDDK supported, multidisciplinary program that encourages interactions between basic scientists and clinical investigators taking part in both basic scientific and translational research to understand the pathophysiologic mechanisms that lead to GI diseases and to design therapeutic approaches based on that understanding.

Location of Hopkins DDBTRCC investigator laboratories in relation to collaborators and cores   Hopkins DDBTRCC Principal Investigator Laboratories and Cores (Ross Research Building, 9th Floor)   Center Organization Center Organization Chart